IS REYE'S SYNDROME CAUSED BY AUGMENTED RELEASE OF TUMOUR NECROSIS FACTOR?
نویسندگان
چکیده
منابع مشابه
Is Reye's syndrome caused by augmented release of tumour necrosis factor?
Reye's syndrome affects children with a history of viral infection treated with aspirin. Its pathogenesis is unclear. Tumour necrosis factor (TNF) is released by macrophages activated by viral infection, endotoxin, and phagocytosis, and it has been shown to be a mediator of the toxic and metabolic effects of endotoxaemia. The metabolic effects of endotoxin and TNF are similar to those found in ...
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The purpose of this study was to evaluate the effect of theophylline on tumour necrosis factor-alpha (TNF-alpha) release by human blood monocytes (BMo), and rat BMo and alveolar macrophages (AM). BMo and AM were incubated in the absence or presence of theophylline, and the cell-free supernatants were harvested and tested for TNF-alpha activity by bioassay. Theophylline dose-dependently reduced ...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1986
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(86)91947-1